Uso de nitroglicerina subcutánea como donante de óxido nítrico en colgajos fasciocutáneos de retardo en ratas diabéticas tipo 1
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El retardo vascular, conocido también como fenómeno de retardo, es el efecto del cambio en el tejido isquémico para incrementar su vascularidad antes de ser transferido, esto mejora la sobrevida del colgajo, incrementa la relación largo-ancho en los colgajos de patrón al azar y lleva a la transferencia de mayores volúmenes de tejido, esta técnica es utilizada por cirujanos plásticos desde hace cientos de años. La necrosis parcial o total del colgajo persiste como una causa de morbilidad en los pacientes con factores de riesgo como diabetes mellitus, trauma extenso y pérdida masiva de tejidos; la L-Arginina, un precursor de óxido nítrico (NO) disminuye la extensión de la necrosis de los colgajos.
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