Marcadores inmunohistoquímicos para virus de papiloma humano. Revisión sistemática
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Este documento se centrará en los biomarcadores de proteínas actualmente bajo investigación para su uso en la detección del cáncer de cuello uterino que parecen mejorar la detección de las mujeres en mayor riesgo de desarrollar cáncer cervical, incluyen- do Ki-67, p16INK4a, BD ProEx C, y Cytoactiv HPV L1. Estos biomarcadores tienen un papel importante en la clasificación de los casos de citología indeterminada, la discriminación de cierto alto grado de displasia cervical de imitadores en la histología, y puede servir como marcadores predictivos para identificar las lesiones con más probabilidad de desarrollar una enfermedad de alto grado y el cáncer cervical.
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Cuzick J, Clavel C, Petry KU, et al. Overview of the European and North American studies on HPV testing in primary cervical can- cer screening. Inter J Cancer 2006; 119: 5: 1095-101.
Fahey MT, Irwig L, Macaskill P. Meta-analysis of Pap test accuracy. Am J Epidemiol 1995; 141(7): 680-9.
Sherman ME, Schiffman MH, Lorincz AT, et al. Toward obje- tive quality assurance in cervical cytopathology: correlation of cyto- pathologic diagnoses with detection of high-risk human papillomavi- rus types. Am J Clin Pathol 1994; 102(2): 182-7.
Malinowski DP. Molecular diagnostic assays for cervical neo- plasia: emerging markers for the detection of high-grade cervical disease. Bio Techniques 2005; (Suppl.): 17-23.
Wentzensen N, von Knebel Doeberitz M. Biomarkers in cervi- cal cancer screening. Disease Markers 2007; 23(4): 315-30.
Endl E, Gerdes J. The Ki-67 protein: fascinating forms and an unknown function. Experimental Cell Research 2000; 257(2): 231-7.
Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cel Physiol 2000; 182(3): 311-22.
Keating JT, Cviko A, Riethdorf S, et al. Ki-67, cyclin E, and p16INK4a are complimentary surrogate biomarkers for human papi- lloma virus-related cervical neoplasia. Am J Surg Pathol 2001; 25(7): 884-91.
Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Natu- re 1995; 375(6531): 506-10.
Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Na- ture 1993; 366(6456): 704-7.
Khleif SN, Degregori J, Yee CL, et al. Inhibition of cyclin D- CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proceedings of the National Academy of Sciences of the United States of America 1996; 93(9): 4350-4.
Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Expression status of p16 protein is associated with human papilloma- virus oncogenic potential in cervical and genital lesions. Am J Pathol 1998; 153(6): 1741-8.
Labib K, Diffley JF. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase? Current Opinion in Genetics and Development 2001; 11(1): 64-70.
Moyer SE, Lewis PW, Botchan MR. Isolation of the Cdc45/ Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proceedings of the National Aca- demy of Sciences of the United States of America 2006; 103(27): 10236-41.
Freeman A, Morris LS, Mills AD, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malig- nancy. Clin Cancer Res 1999; 5(8): 2121-32.
Gonzalez MA, Tachibana KEK, Laskey RA, Coleman N. Control of DNA replication and its potential clinical exploitation. Natu- re Reviews Cancer 2005; 5(2): 135-41.
Branca M, Giorgi C, Ciotti M, et al. Over-expression of to- poisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment. Inter J Gynecol Pathol 2006; 25(4): 383-92
Chen Y, Miller C, Mosher R, et al. Identification of cervical cancer markers by cDNA and tissue microarrays. Cancer Res 2003; 63(8): 1927-35.
Rosty C, Sheffer M, Tsafrir D, et al. Identification of a proli- feration gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene 24(47): 2005; 7094-104.
Santin AD, Zhan F, Bignotti E, et al. Gene expression profi- les of primary HPV16- and HPV18-infected early stage cervical can- cers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Viro- logy 2005; 331(2): 269-91.