Producción de iNOS y nitración de proteínas en la aorta de ratas expuestas a ozono
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El ozono (O ) es el principal contaminante fotoquímico del aire, reacciona directamente con biomoléculas en el aparato respiratorio y genera estrés oxidativo directo y sistémico. Induce liberación de citocinas, expresión de la sintasa inducible de óxi- do nítrico (iNOS) y reclutamiento de leucocitos. El óxido nítri- co (NO) reacciona con superóxido (O -) para formar peroxini- trito (OONO-), el cual nitra tirosina y forma nitrotirosina.
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